Let’s talk ↗Company updates, case studies and practical thinking on AI-powered microscopy image analysis.
High content screening (HCS) is a powerful tool for understanding the effects of drugs, small molecules, and genetic manipulations on cells. The process involves imaging cells at high throughput and using software to analyze the images and extract quantitative data. The extracted data then needs to be further analyzed and processed into reports and visualization. […]
Read article →TK Analytics marked its presence at the SLAS 2024 conference in Boston with a focused exhibition on AI-based phenotypic screening, demonstrating our leadership in this innovative area. Our team engaged in meaningful discussions with industry peers, sharing insights and exploring the latest trends in laboratory automation and screening. Our participation in the Innovation AveNEW showcased […]
Read article →Abstract Our study on HMSN2C, a rare axonal neuropathy linked to TRPV4 gene mutations, utilized the JUMP CP dataset. Analysis yielded 3612 hits, with 87 found in a drug repurposing library. Literature review revealed three promising TRPV4 antagonists within this subset, offering potential therapeutic options for HMSN2C. Download a PDF version of this case study. […]
Read article →In the realm of early-stage drug discovery, the quest to understand the intricate interplay between genes and observable traits, known as phenotypes, is pivotal. This understanding holds the key to discovering new therapeutic avenues and revolutionizing the treatment of diseases. A crucial aspect of early-stage drug discovery is the analysis of high-throughput image data, a […]
Read article →CytoData symposium and hackathon brings together researchers interested in image-based profiling of biological phenotypes. The symposium including workshops, presentations and a poster session, followed by a hackathon for developers during the last two days of the event.The CytoData Society is bringing together a community of scientists from academia and industry to discuss the latest advances […]
Read article →We’re thrilled to announce that TK Analytics has been selected to join the NVIDIA Inception Program, a prestigious initiative designed to accelerate the growth of startups innovating in AI and data science. By aligning with NVIDIA, we don’t just gain access to the world-class GPU technology, but also to an ecosystem brimming with knowledge, training, […]
Read article →Phenotypic profiling, the study of observable characteristics resulting from the interaction of genes with the environment, plays a pivotal role in understanding complex biological processes and identifying potential therapeutic targets. With the rapid advancements in Artificial Intelligence, researchers and scientists now have a powerful tool at their disposal to enhance phenotypic profiling. At TK Analytics […]
Read article →High Content Screening (HCS) has revolutionized the field of drug discovery by enabling the analysis of multiple parameters of cells in a single assay. HCS generates a vast amount of data that requires sophisticated analytical tools to extract meaningful information. Using a standardized assay, such as cell painting, we generate datasets that: 1) can be […]
Read article →As we’re primarily based in Slovenia, and we’re currently hiring locally, the job posting below is in Slovenian. V startupu TK Analitika iščemo junior python/AI razvijalca oz. razvijalko. Kdo smo? Razvijamo tehnologije za odkrivanje novih zdravil s pomočjo mikroskopije in napredne analize slik. Naše stranke so farmacevtska podjetja in druge organizacije, z našimi rešitvami […]
Read article →In the field of chemical research, computational methods have become indispensable for predicting toxicity and exploring vast chemical spaces. There are two powerful tools that we can use to predict the toxicity of chemicals: ProTox-II and ChemProp. ProTox-II is a web server that predicts the toxicity of chemicals, while ChemProp is a machine learning model […]
Read article →The European edition of SLAS conference has been placed in Brussels, next to the famous Atomium. Although smaller than the international edition, it provided plenty of interesting posters and presentations. In the scientific content there was less emphasis on automation and more on screening, particularly drug repurposing and organoid research. Interestingly, there was a strong […]
Read article →Our team is visiting the SLAS Europe 2023 Conference and Exhibition in Brussels, Belgium next week. After a successful SLAS 2023 conference in San Diego a few months ago, this is another opportunity to connect with our clients and discuss the latest developments in our field – this time with a European twist. If you’d […]
Read article →Swiss Biotech Day (SBD) is an annual event taking place at the heart of Swiss pharma industry – Basel for more than 10 years. A two-day conference brought together Swiss and international biotech professionals and companies. The main topics were related to the position of the biotech industry in Switzerland, its influence beyond its borders […]
Read article →Our team is attending the Swiss Biotech Day 2023 conference, in Basel, Switzerland. At one of the leading biotech events in Europe we’ll use the opportunity to connect with our European clients, while also following the latest advances in our field. If you’d like to meet us and discuss the importance of data science and […]
Read article →Image segmentation is an essential process and one of the first challenges in analyzing images of complicated cellular phenotypes at the single cell level. Accurate and efficient segmentation is crucial for extracting meaningful information from images and analyzing biological processes. In recent years, several software tools have been developed to automate the segmentation process, including […]
Read article →Another SLAS 2023 conference wrapped up at the dawn of March in San Diego. It was packed with interesting talks, posters and exhibitors. Here we’ll showcase some of the most interesting talks, posters and products. The centre of the stage are of course robots. SLAS was full of them and it’s always fascinating to watch […]
Read article →The TK Analytics team is currently visiting the SLAS2023 Conference and Biocom Global Life Science Partnering & Investor Conference in San Diego, CA. We are always looking for opportunities to connect with our clients and discuss the latest developments in our field, and these two events are the perfect opportunity for us to do just […]
Read article →Preprocessing extracted features from cell painting images is an essential step in image-based profiling because it helps to ensure that the data is of high quality and is ready for further analysis. This can help to eliminate sources of error or bias in the data, such as differences in the amount of sample material or […]
Read article →High content screening (HCS) is a powerful tool for understanding the effects of drugs, small molecules, and genetic manipulations on cells. The process involves imaging cells at high throughput and using software to analyze the images and extract quantitative data. In this case study, we will be examining the work we did with a company […]
Read article →The verification of image quality in high throughput experiments is virtually impossible to do by hand, that is why you can use automated methods to objectively label and remove images and cells that are affected by artifacts. These strategies aim to reduce the possibility of inaccurate values affecting your data. Field-of-view quality control When we […]
Read article →Image analysis is the process of converting digital information from images into measurements that characterize the status of each and every cell in an experiment. A digital image is basically a n-dimensional array of pixels, where each of the pixels has its own value (i.e., 0-255, for an 8-bit image). We can map these values […]
Read article →When looking at the microscopy images of ER exit sites we noticed that after a certain perturbation they change the distribution around the nuclei. ER exit sites in normal cells are more concentrated on one side. After the perturbation, the ER exit sites uniformly distribute around the nuclei. We wanted to quantify this phenotype, so […]
Read article →The structure of mitochondria has been linked to disruptances in cellular processes, such as energy metabolism, calcium storage and lipid synthesis. Since mitochondria can be easily stained and imaged, it is also possible to measure their dimensions and detect whether an intervention affects their size or structure. We developed a simple algorithm to measure the […]
Read article →The term “Cell painting” was first coined in 2016, by Bray et al., describing a morphological profiling assay to reveal eight broadly relevant cellular components or organelles by multiplexing six fluorescent dyes in five different channels. In addition, they designed an automated image analysis software to generate a rich profile for detecting subtle phenotypes in […]
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